Commentary: Advent of sibling designs

Commentary: Advent of sibling designs.

Association of tobacco and lead exposures with attention-deficit/hyperactivity disorder. Pediatrics 2009;124: e1054–63. 22 Biederman J, Monuteaux MC, Faraone SV, Mick E. Parsing the associations between prenatal exposure to nicotine and offspring psychopathology in a nonreferred sample. J Adolesc Health 2009;45:142–48. 23 Thapar A, Rice F, Hay D, Boivin J et al. Response to: testing the associa...

Advent of Elkosin

Commentary: Migrant study designs for epigenetic studies of disease risk.

A molecular epidemiology project on diet and cancer: the EPIC-Italy prospective study. Design and baseline characteristics of participants. Relative validity and reproducibility of a food frequency dietary questionnaire for use in the Italian EPIC centres. Valle C et al. B-vitamins intake, DNA-methylation of one carbon metabolism and homocyst-eine pathway genes and myocardial infarction risk: t...

Commentary on 'Designs for dose-escalation trials with quantitative responses'.

Bailey (Statist. Medi 2009; this issue) puts the focus on efficiency in dose-finding studies and shows that some quite simple modifications to much current experimentation can lead to significant efficiency gains. Efficiency has not been the main focus of interest in this field, in particular when dealing with situations requiring other than healthy volunteers. Dr Bailey's results are important...

Commentary: Flawed study designs are not salvaged by large samples.

randomised trial evidence? Lancet 2004;363:1724–27. 46 Hung HC, Joshipura KJ, Jiang R et al. Fruit and vegetable intake and risk of major chronic disease. J Natl Cancer Inst 2004;96:1577–84. 47 Welch AA, Bingham SA, Ive J et al. Dietary Fish Intake and plasma phospholipid n-3 polyunsaturated fatty acid concentrations in EPIC Norfolk. Am J Clin Nutr 2006;84: 1330–39. 48 Bingham S, Gill C, Welch ...